A mule is the offspring of a male donkey and a female horse. Mules and are almost always sterile (although there are rare cases of fertile mules). Horses and donkeys are different species, with different numbers of chromosomes; this sterility is attributed to the differing number of chromosomes of the two species: donkeys have 62 chromosomes, whereas horses have 64.
Hybrid animals like mules, which are the product of horses and donkeys, are almost always sterile because the species they are comprised of have a different number of chromosomes. Horses have 64 while donkeys have 62 chromosomes, resulting in offspring with an odd number of chromosomes (63). This odd number prevents the chromosomes from pairing up to create successful embryos.
Mules are crossbred between donkeys (62
Chromosomes) and horses (64 chromosomes). Mules are subsequently born with 63 chromosomes. This prevents their chromosomes from pairing up and creating
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