According to the World Health Organization, the most deadly disease as of 2004 was HIV, accounting for 6.9 percent of deaths via infectious disease worldwide. Tuberculosis is the runner-up, claiming 2.7 of human lives.
Smallpox has claimed more human lives than any other disease in world history. In just the 20th century, it killed up to 500 million people, and mass immunization began in 1959. Today, smallpox doesn’t even make the top ten list for yearly disease deaths. Malaria is #2 for most human deaths ever, and it killed between 80,000 and 250,000 people in the 20th century alone.
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