This is probably a tie between Clostridium botulinum (botulism) and Escherichia Coli (E. Coli). Botulism is capable of causing breathing difficulty and other severe problems, as it attacks the nervous system, while in three to five percent of cases E. Coli can cause kidney and liver failure. Food poisoning is never pleasent, but there are things much worse than throwing up for a few days.
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