See previous answers.
Lack of funding, insufficient access to previous work, inadequate peer review, lack of constructive input, lack of assistance, etc etc.
Lack of roots in the scientific community would pose a significant road block. Not only would there be a lack of grant money, peer review, and scientific resources, but it would also lack an air of legitimacy, i.e., people may not take you as seriously. It would also be harder to publish your findings.
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