This is hard to answer, because it could be just about anything. It could just be a sensitivity to the fragrance or bleach used in the detergent. Some people are allergic to some brands of detergents and not others. It may also just be that a person has very sensitive skin that is easily irritated by chemicals in general. It depends on the brand of detergent and the specific allergy; a good way to try deal with detergent allergies is to go with fragrance-free detergent, to try different brands to see if some formulas are better or worse, and to try alternative, natural cleaning agents such as baking soda.
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