This depends on the severity of the gangrene. Sometimes surgically removing the dead tissue (debridement) is enough – if it’s in a limb, it may not need complete amputation. Antibiotics are usually ineffective on their own due to weak penetration of ischemic (lacking blood supply) muscles. Since gangrene is the decay of already dead tissue, there’s no way to restore it to life, and it needs to be removed to stop the spread of infection and cell death.
There are antibiotics available that can treat gangrene. Acetonitrile and enzymes are also effective. As early as 1028, fly maggots were also used to treat gangrene. This is sometimes still used when the condition is very severe.
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