Depends on what you mean by high. Mammals and everything else will still be able to breathe just fine if the atmospheric CO2 levels go above the dreaded 450 ppb mark. (how well we will live will be another story though). At current levels CO2 makes up about .036% of Air by volume. 1% by volume of CO2 would cause drowsiness after prolonged exposure. 2% can cause an increase in blood pressure and pulse rate. 5% it starts to cause headaches, shortness of breath, dizziness, confusion, and can cause panic attacks. At 8% a ten minute exposure will cause loss of consciousness.
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