I have attached a link to a webpage comparing bison with the common ranch animals. Here is a quick run down to answer your question:
Fat: Bison=2.4 g Beef=around 9 g
Calories: Bison=143 kcal Beef=210 kcal
Cholesterol: Bison=82 mg Beef=86 mg
Iron: Bison=3.42 mg Beef=2.99 mg
Vitamin B12: Bison=2.86 mcg Beef = 2.65 mcg
Bison is a healthier red meat with more nutrition than beef. However bison population is far lower than bovine population. The choice and preference are yours.
One interesting fact is that it is illegal to inject bison with any antibiotics or growth hormones, resulting in a more naturally raised food source.
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