It’s hard to qualify “knowing” — it implies that we fully understood the implications of our actions. We’re still not entirely aware of our impact on the planet to this day. However, I’d say that, when we hunted the dodo to extinction, we did it intentionally — the intent probably wasn’t extinction, but it was to exploit every dodo we could find. We have also all but caused the extinction of some diseases, such as smallpox or polio.
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