Yes. As a matter of fact, there have been quite a few outbreaks of the plague since the middle ages, though none have been quite as devastating. The Third Pandemic (the Black Death was the second major outbreak of plague, after the Justinian Plague in 6th century AD) broke out in China, and spread throughout the continent during the mid to late 19th century. In all, the Third Pandemic caused about 12 million deaths.
In the 1910s, another outbreak occured in Manchuria, resulting in 60,000 deaths; and about ten years later, a second flare-up in Manchuria caused an additional 60,000 deaths.
Most recently, an outbreak in The Democratic Republic of Congo resulted in 50 deaths in 2006.
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