The EPA maintains that DEET in bug spray is safe if used in moderation. Long-term use, however, could potentially be dangerous. They offer ways in which to reduce potential harmful effects and responsible use. These tips include things like don’t apply over cuts, wounds, or irritated skin, under clothing and don’t over apply. They also don’t encourage putting on hands of young children and recommend that the user wash clothes before wearing again and to wash treated skin once indoors again.
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