Yes. The most high profile is a result of over-fertilization and pesticide use on freshwater mussel farms (where pearls are farmed), which can upset the natural balance downstream from freshwater pearl farms by causing eutropification. Eutropification occurs when algae grows to such an extent downstream from this treatment that it completely fills the lakes and streams, then dies, sinks to the bottom and decomposes, sucking up all available oxygen and killing everything else in the water. This is obviously damaging to the environment.
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