Yes, it is possible. According to the NY Times, hybridization between distinct species is actually pretty common, up to about 10% for animal species and 25% for plant species. A hybrid of a horse and zebra is called a zorse. However, a lot of hybridization occurs with the aid of humans. Hybrids often are infertile, so that is not very favorable in terms of natural selection.
Yes a successful breeding can happen and the offspring is called a zebroid. While breeding between horses and zebras do not happen in the wild, zebras can breed with any other species in the equine family. These types of hybrids can only take place in captivity.
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