There is no evidence to suggest that a person can develop an immunity to black widow venom. Although its a very interesting topic, it is not one that is very easy to research because it would involve humans willing subjecting themselves to being bitten by a very venomous spider. Also, with any spider bite, it is not too easy to identify what type of spider (if a spider at all) was responsible for a bite. The human immune system can develop B cells which produce antibodies to help fight off invading pathogens after first being exposed to a certain substance. It is possible that this could occur after first being exposed to a black widow’s venom in some rare cases, although it is not very likely and no evidence currently supports this theory.
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