Yes, with the Gulf of Mexico being the best example of excessive agricultural runoff. The Gulf is horribly affected by increased levels of plant nutrients, such as nitrogen and phosphorus, thanks to ag runoff. These chemicals can increase plant growth within waterways, a process called eutrophication, which can in turn lead to an ecological upset of the water system. Increased plant growth in water filters sunlight that enters the water, can increse water temperatures, can reduce the oxygen, and create habitat for non-native species. All of these factors can harm the endemic species, and ultimately lead to a crash in the ecosystem.
Agricultural runoff, pesticides, waste all have polluted the Mississippi River. It flows down into Louisiana and feeds out into the Gulf of Mexico, where it has formed the Dead Zone (which runs all the way to the Mississippi border of Louisiana and the Texas border). The area is formed by all the harmful things that have polluted the Mississippi including agricultural runoff. The reason why it is called the Dead Zone is because there is no oxygen left for animals and plants to survive
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