If you consider chemicals and fertilizers as pollution, then yes. If you go to the causes on the wikipedia page, you’ll learn in greater detail about the causes.
Dead zones are created when very high levels of nitrogen and phosphorous rich fertilizers enter an aquatic system. The nitrogen causes algae and other aquatic plants to grow rapidly and create and algae bloom. When the algae die off, they deplete the water of oxygen, which in turn creates the dead zone. It is very difficult, if not impossible for organisms that require oxygen to live in dead zones. Below is a NASA photo of an algae bloom in the Gulf of Mexico.
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