We have all heard the downsides about bullying, but were you aware that bullying can affect a genetic sequence so as to make you more susceptible to disease and immunodeficiency? A recent study on rhesus macaque monkeys proves that there is some correlation between being bullied and poor health.
Jenny Tung, an associate professor at Duke University who helped lead the study, set out to find what if any health implications could be associated with social standing. But first, she needed a subject: enter 49 female rhesus monkeys. For the study to begin, the monkeys were split into 10 different groups, each with 5 monkeys a piece. An animal’s social ranking was decided by how early on (or late) each monkey was introduced into the sample group—the earlier an animal was introduced, the higher social ranking that animal was granted by the group.
By examining how the newly introduced animals were treated by their group mates, researchers were able to glean a good deal about where each individual monkey stood socially. “Lower-ranking females are exposed to a different social environment,” Tung explained of the method. “Day to day, they are subject to more stressful interactions. There are particular threatening faces and gestures that female macaques can make to each other. [The low-ranking females] tend to be the target of those threat gestures more often.”
In short, the monkeys with the least amount of time spent in the social setting—those on the lowest ‘totem’ as far as social ranking is concerned—were more likely to also become bullied by the animals that were able to socialize for a longer period of time. And that was just the start of it, for the next step of the study researchers had to gather and examine the animal’s genes in order to help get a better look at deficiencies that may or may not exist within the fine coding. While looking at the macaque’s genes, researchers found that those of the lowest order (those treated the harshest by the others) were more likely to have inflamed and, therefore, ‘active’ genes.
Since inflamed genes were directly connected to the immune system, it was then determined that those animals with the higher level of inflamed genes (those under stress, again) were more likely to have a compromised immune system. Tung found that “When some macaques’ status changed after a newcomer arrived, so did their patterns of immune system gene activity.”
For an immune system that has been compromised, bullying can mean a lot more than harsh words and hurt feelings. When a person’s health is at stake, bullying becomes that much greater of an issue and not something to be taken lightly. But just as the topic raises concerns, a possible reconciliation is illuminated. That is the idea that a sequence of genes can repair itself (or heal, so to speak) as it climbs up the social ladder. Things like confidence and camaraderie can heal on this very basic level. “We were able to find that with changes in social environment, you see the gene-expression pattern seems to change with it,” said Tung. “If you can improve your social environment, then that gene signature seems to go away too.” And that is something to be confident in.
Photo Credit: commons.wikimedia.org/wiki/File:Rhesus_Macaques_-_cropped.jpg